More of these 'arms' will open up more blocks for use, making the game easier. Although there are no strict layout rules, most traditional Mahjong setups use four jutting arms, fixed facing horizontally on the four corners of the square pyramid. This will offer the game a sense of unpredictability.
Although you don't need to adhere to the traditional setup, it's a good idea to give it a try at least once. A traditional Mahjong set-up uses 144 blocks in a rough 'spider' shape, with three extra layers added on top like a pyramid, making it a 3D puzzle.